Section: Partnerships and Cooperations

National Initiatives

PEPS JCJC INS2I 2016 Modeling and simulation of the oscillatory activity of the memory system during sleep and under general anesthesia (L. Buhry, L. Bougrain).

In order to better understand the mechanisms of amnesia under anesthesia, we propose, on the one hand, to carry out a comparative study, to model and simulate the hippocampal oscillatory activity under general anesthesia and during sleep (tasks 1 and 2). Deep SEEG recordings in epileptic patients during seizures will serve as a reference for modeling and simulation. On the other hand, on the basis of data recorded during sleep, we wish (tasks 3 and 4) to analyze and model the interactions between two structures involved in memory, the hippocampus and the prefrontal cortex, and (tasks 5) propose an automated method to reveal markers of the hippocampal activity characteristics of the sleep stages making use of sole surface recordings. *As it is widely acknowledged that the consolidation of memory occurs mostly during the deep sleep stages, this should make it possible to distinguish the parts of the signal corresponding to periods of consolidation and to propose, through mathematical modeling and simulation, mechanisms explaining the effects of amnesia, or even the absence of memory formation under general anesthesia.